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Reading: MPO-ANCA Associated Vasculitis Following COVID-19 Vaccination – A Case Report


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MPO-ANCA Associated Vasculitis Following COVID-19 Vaccination – A Case Report


Mahmoud Khalifa ,

BronxCare Health System, US
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Yara Adel Altahan,

Royal College of Surgeons in Ireland, RCSI, IE
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Paavana Varanasi

BronxCare Health System, US
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Whether autoimmune or rheumatic disease can be precipitated after vaccination is controversial. Only epidemiological studies or clinical trials with an extremely large sample size can allow for a consistent assessment of the relative risk of vaccine-related incidence. Studies with such large sample sizes are complex, difficult to perform, and costly, which limit their administration. There exists no minimum criteria for diagnosing vaccine-related autoimmune diseases, this question must be analyzed on a case-by-case basis.

Although our report does not prove a causal association between vaccination and vasculitis, it seems possible that in rare cases, vaccination might induce vasculitic disease. While the possibility of autoimmune disease is very real, without vaccinations the SARS-CoV-2 pandemic will spread unchecked, bringing with it a slew of multisystem disorders, including autoimmune diseases both in the present and future (Table 1, Figures 1, 2).

How to Cite: Khalifa, M., Altahan, Y.A. and Varanasi, P., 2021. MPO-ANCA Associated Vasculitis Following COVID-19 Vaccination – A Case Report. Journal of Scientific Innovation in Medicine, 4(2), p.5. DOI:
  Published on 24 May 2021
 Accepted on 04 May 2021            Submitted on 04 May 2021

Table 1

Results of the workup for renal failure.


C3 135.0 [90.0–150.0 mg/dL]

C4 20.0 [16.0–47.0 mg/dL]

Anti-nuclear antibody (ANA) screen Negative

Anti-Glomerular basement membrane antibody Undetectable

Anti-DNA antibody Undetectable

ANCA-MPO antibody 535.4 AI

ANCA-Proteinase-3 antibody Undetectable

Figure 1 

CXR showing diffuse bilateral interstitial/alveolar airspace infiltrates.

Figure 2 

HRCT chest showing spiculated densities in the bilateral lung apices.

Competing Interests

The authors have no competing interests to declare.

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