Start Submission Become a Reviewer

Reading: Pediatric Skin and Soft Tissue Infection Antibiogram and Antibiotics Prescription Pattern in...


A- A+
Alt. Display

Published Abstracts

Pediatric Skin and Soft Tissue Infection Antibiogram and Antibiotics Prescription Pattern in the Pediatric Emergency and In-Patient Settings


Matthias Manuel ,

BronxCare Health System, US
X close

Prarthana Parthasarathy,

BronxCare Health System, US
X close

Mrudula Premkumar,

BronxCare Health System, US
X close

Roy Vega,

BronxCare Health System
X close

Lin Kin

BronxCare Health System, US
X close
How to Cite: Manuel, M., Parthasarathy, P., Premkumar, M., Vega, R. and Kin, L., 2019. Pediatric Skin and Soft Tissue Infection Antibiogram and Antibiotics Prescription Pattern in the Pediatric Emergency and In-Patient Settings. Journal of Scientific Innovation in Medicine, 2(2), p.7. DOI:
  Published on 28 Jun 2019
 Accepted on 19 Jun 2019            Submitted on 19 Jun 2019


Antimicrobial resistance has posed significant challenge to effective treatment of pediatric skin and soft tissue infections (SSTIs) in the past two decades with significant demographic variations. The AAP Committee on Infectious Disease recommends tracking of local antibiotic resistance patterns, judicious use of empiric antibiotics in line with resistance patterns and antibiotic stewardship to combat this challenge.


Characterization of pediatric SSTI antibiogram and antibiotic prescription pattern, with specific evaluation of MRSA prevalence, antibiotic resistance and prescription patterns.


We conducted a retrospective review of patients aged 0–21 years seen at the Emergency and In-patients units of the BronxCare Health System from Jan. 2013 to Dec. 2016. Study was IRB-approved and data was collected using ICD-9 and 10 codes for key words. Specific information about patient demographics, type of SSTI, empiric antibiotics prescribed, culture results and antibiotic sensitivities were obtained from the EHRs. Data was analyzed using SAS 9.3® with bivariate comparison tested at α = 0.05 significance level. The antibiogram was created with the WHONET software.


Records for 2872 children were reviewed – 52% were females, mean age was 10 years, and 75% self-identified as Black or Hispanic. The majority (80%) presented with abscess or cellulitis with mean size of 4.0cm, predominantly affecting the extremities (31%), gluteal and groin regions (14%) and head and neck regions (10%). Seventy-one percent (71%, n = 574) of 811 cultures sent were positive, with Staphylococcus aureus and Group A Streptococcus reported in 83% and 5% of positive cultures, respectively. The prevalence of methicillin-resistant S. aureus (MRSA) was 28% (39% of positive cultures), with 18% of MRSA demonstrating inducible Clindamycin resistance. MRSA was 99.1% sensitive to TMP-SMX. During the period under review, there was a trend towards decreasing sensitivity of MRSA to clindamycin (from 93% to 75% with p = 0.071). Despite the observed pattern, clindamycin constituted 70% of all empiric antibiotics prescribed, with only 1.0% receiving TMP-SMX at their initial encounter.

Table 1

Temporal Trend in MRSA Resistance.

PTrend = 0.036 2013 2014 2015 2016

Clinda – R 12 (17.5%) 4 (7.0%) 12 (22.6%) 11 (25.0%)
Clinda – S 57 (82.6%) 53 (92.9%) 41 (77.4%) 33 (75.0%)
TMP-SMX – R 0 (0.0%) 0 (0.0%) 0 (0.0%) 2 (4.8%)
TMP-SMX – S 69 (100.0%) 57 (100.0%) 51 (100.0% 40 (97.2%)

Abbreviations – Clinda: Clindamycin, TMP-SMX: Trimethoprim-Sulfamethoxazole, R: Resistance, S: Sensitive

Table 2

Temporal Trend in Empiric Antibiotics Prescription Pattern.

Ptrend = <0.001 2013 2014 2015 2016

Augmentin 33 (7.7%) 28 (6.9%) 24 (4.8%) 13 (3.4%)
TMP-SMX 8 (1.9%) 7 (1.7%) 2 (0.4%) 3 (0.8%)
Clindamycin 235 (54.7%) 278 (68.8%) 368 (74.2%) 312 (81.0%)
Cephalexin 110 (25.6%) 69 (17.1%) 73 (14.7%) 46 (11.9%)
All Antibiotics 430 404 496 385


Our data shows a high prevalence of MRSA in this population of children with SSTI, with an increasing resistance to Clindamycin, but excellent sensitivity to TMP-SMX. Despite these patterns, clindamycin remains the predominant empiric antibiotic prescribed for SSTIs in the Pediatric ED and In-patient settings. Clinicians should consider utilizing local antibiogram in prescribing empiric antibiotics, and also follow culture results to make appropriate antibiotic changes for effective clinical response.

comments powered by Disqus